Abstract. This article focuses on the multifaceted phenomenon of stress and explores its complex interaction with human health in physiological, psychological and sociocultural aspects. The article explores the biopsychosocial aspects of stress, elucidating its complex dynamics and far-reaching consequences. Central to this is an in-depth analysis of physiological responses to stress, encompassing the immune, cardiovascular and endocrine systems, and how chronic stress dysregulates these vital processes. The psychological consequences of stress are examined with emphasis on its role in causing such conditions as anxiety, depression, sleep disorders and emotional burnout, and are complemented by real life examples. The societal relevance of this research is highlighted, and emphasis is placed on how the knowledge gained can contribute to public health initiatives and inform of individual coping strategies.